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What factor can necessitate financial disclosure?

  1. Any payment from the sponsor

  2. Compensation to PI affected by study outcome

  3. Travel expenses covered by the sponsor

  4. Any association with the sponsor

The correct answer is: Compensation to PI affected by study outcome

Financial disclosure refers to the reporting of financial interests and relationships related to a particular study. In this case, the question asks for the factor that may require financial disclosure. Option A and C are incorrect because they both suggest financial transactions or benefits from the sponsor, but they do not directly address the need for disclosure. Option D implies a connection with the sponsor, but this alone does not necessarily require financial disclosure. Only option B refers to compensation specifically for the principal investigator (PI) and how it may be impacted by the outcome of the study, making it the correct answer in this context.